Dr. Shlomo Sasson received his Ph.D. in Biochemistry in 1981 from the Hebrew University of Jerusalem. He spent a 3-year post-doctoral training with Dr. Angelo C. Notides at the University of Rochester, (Rochester NY, USA), where he investigated the mechanism of action of antiestrogens. He returned to Israel for a second post-doctoral position with Dr. Erol Cerasi at the Hebrew University- Hadassah Faculty of Medicine, where he started his diabetes research career and discovered the phenomenon of autoregulation of glucose transport. He 1986 he was appointed Lecturer at the Department of Pharmacology where he continued his academic career and the same line of research. Since then he and his research team progressed to develop novel antihyperglycemic drugs, study the role of lipid peroxidation in diabetes and investigate vascular endothelial cell -β-cell interactions in islets of Langerhans.
Dr. Sasson teaches pharmacology to medical, veterinary and pharmacy students and has been awarded many excellent teaching awards and prizes based on students’ evaluations. He also received local and international prizes for his research and academic activities. He serves regularly on local and international policy making committees as well as on grant review committees.
Main research topics:
· Regulation of the glucose transport system in vascular endothelial and smooth muscle cells and in skeletal muscles.
· Development of novel antihyperglycemic compounds: (a) insulin mimetics that induce glucose transporter translocation to the plasma membrane of skeletal muscles cells. (b) Allosteric activator of glucose transporter-4 that enhance glucose influx in myotubes.
· Investigation of the mechanism by which lipid peroxidation by-products augment insulin secretion from β-cells.
· Studies on bi-directional interactions between β-cells and microcapillary endothelial cells in islets of Langerhans.
1. Gruzman, A., Shamni, O., Ben Yakir, M., Sandovski, D., Elgart, A., Alpert, E., Cohen, G., Hoffman, A., Kazthendler, Y., Cerasi, E., Sasson, S. (2008). Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase a. J. Med. Chem. 51:8096-8108.
2. Gruzman, A., Babai, G. and Sasson, S. (2009). Adenosine momophosphate-activated protein kinase (AMPK) as a new target for antidiabetic drugs: a review on metabolic, pharmacologic and chemical considerations. Rev. Diab. Stud. 6:13-36.
3. Riahi, Y., Sin-Malia,Y., Cohen, G., Alpert, E., Gruzman, A., Eckel, J., Staels, B., Guichardant, M., and Sasson, S. (2010). The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal (4-HDDE) and PPARd. Diabetes, 59:808-818.
4. Lamers, D, Schlich, R., Greulich, S., Sasson, S., Sell, H. and Eckel, J. (2011). Oleic acid and adipokines synergize in inducing proliferation and inflammatory signaling in human vascular smooth muscle cells. J. Cell. Mol. Med. 15:1177-1188.
5. Negre-Salvayre, A., Auge, N., Ayala, V., Basaga, H., Chapple, S., Cohen, G., Feher, J., Grune, T., Lengyel, G., Mann, G.E., Poli, G., Portero-Otin, M., Riahi, Y., Salvayre, R., Sasson, S., Shamni, O., Siems, W., Siow, R.C.M., Zarkovic K. and Zarkovic, N., (2010). Pathological aspects of lipid peroxidation. Free Radical Res. 44:1125-1171.
6. Riahi, Y., Cohen, G., Shamni, O., Sasson, S., (2010). Signaling and cytotoxic functions of 4-hydroxyalkenals. Am. J. Physiol.- Endocrinol. Metab. 299:E879-E886.
7. Cohen, G., Riahi, Y., Sasson S. (2011). Lipid peroxidation of poly-unsaturated fatty acids in normal and obese adipose tissues. Arch. Biochem. Physiol. 117:131-139.
8. Gruzman, A. Elgart, A., Viskind, O., Billauer, H., Dotan, S., Cohen, G., Mishani, E., Hoffman, A, Cerasi, E. and Sasson, S. (2012). Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-dithioacetal in diabetic mice. J. Cell. Mol. Med. 16:593-603
9. Cohen, G., Riahi, Y., Shamni, O., Guichardant, M., Chatgilialoglu, C., Ferreri, C., Kaiser, N. and Sasson, S. (2011). The role of lipid peroxidation and PPARδ in amplifying glucose-stimulated insulin secretion. Diabetes 60:2830-2842.
10. Cohen, G, Riahi, Y. and Sasson, S. (2012). Free Radicals and metabolic disorders. In: Handbook of Radicals in Chemistry & Biology (eds. C. Chatgilialoglu and A. Studer). John Wiley & Sons, Chichester, UK. Pp.1679-1700.
11. Gruzman, A., Elgart, A., Viskind, O., Billauer, H., Dotan, S., Cohen, G., Mishani, E., Hoffman, A., Cerasi, E. and Sasson, S. (2012). Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-dithioacetal in diabetic mice. J. Cell. Mol. Med. 16:593-603.
12. Kapitulnik, J., Benaim, C. and Sasson, S. (2012). Endothelial cells derived from the blood-brain barrier and islets of Langerhans differ in their response to the effects of bilirubin on oxidative stress under hyperglycemic conditions. Front. Pharmacol. 3: Article 131,July 2012.
13. Jaganjac, M., Tirosh, O., Cohen, G., Sasson, S. and Zarkovic, N (2013). Reactive aldehydes - second messengers of free radicals in diabetes mellitus. Free Radical Research (in press).
14. Cohen, G., Riahi, Y., Sunda, V., Delpano, S., Chatgilialoglu, C., Ferreri, C., Kaiser, N. and Sasson, S.: Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes. Free Radicals. Biol. Med. (in press).
15. Meltzer-Mats, E., Babai-Shani, G., Pasternak, L., Uritsky, N., Getter, T, Olga Viskind, O., Eckel, J., Cerasi, E., Senderowitz, H., *Sasson, S. and Arie *Gruzman, A. (2012): Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. J. Med. Chem. (in press).